A little perspective... Vast majority do not take Ducati Superbikes on multi-thousand mile trips. Nor are Asian liter bikes often taken on the same. There are better bikes for crossing multiple state lines.
That said, some do take the 2V Multistrada far, and I used to ride my 4V ST4s far. 2 valve syncs are straightforward and not exorbitant. Additionally, after one or two valve check intervals, they tend to stay in spec. There are ST4s riders with 60,000, 80,000 miles on their odometers and haven't had the valves fall out of spec since the 12 or 18K service, and they aren't even checked anymore.