spybot, adaware, and spysweeper are designed to search out only spyware..they normally dont mess with legit programs/files etc. So its usually pretty safe to allow them to delete whatever they find. However, unless your system restore is turned off, xp and or the program ur running will usually set a restore point b/4 it removes any spyware,so if a program u normally use, stops running after using one of these programs, u can just restore xp, or use the restore function built into the removal programs themselves.
I've found that these programs will sometimes find drivers/files left on your computer from games that you play online, so that would be something to look for...but in general, just downloading the basic programs, and letting them run without changing any settings, you'll normally be OK.
